You have two choices: Either quit your job or cancel your gym membership because it turns out that regular physical exercise simply does not undo the disadvantages of sitting at a damn desk for your whole life.

A collection of 40 recent studies on the effects of sitting for a prolonged period of time (like, at your desk at work) shows that prolonged sitting is so harmful to your body that it will likely result in premature death or cardiovascular disease. Even worse, regular intense exercise won’t actually undo the negative effects of sitting at your desk.

Regular exercise, particularly higher levels of physical activity, appears to blunt these harmful effects somewhat but may not eliminate them entirely. An analysis of more than a dozen studies
concluded that we need at least 60 minutes a day of moderately intense exercise (such as brisk walking, doubles tennis or ballroom dancing) to counter the increased risk of premature death due to prolonged sitting. But another study found that the same amount of exercise — which is more than most physically active people get — doesn’t undo the negative effects of sitting on insulin levels and blood fats.

The damage from prolonged sitting is thought to be due to reduced muscle activity, especially in the large muscles of the legs and back, which can decrease the body’s ability to regulate blood sugar and remove harmful blood fats. Sitting for long periods may also adversely affect blood vessel function and increase food cravings, causing us to eat more and gain weight.

To reduce sitting time, there are actions you can take.

At work, stand for a few minutes every half-hour, perhaps during phone calls, coffee breaks or meetings.
If possible, use a desk that lets you work both standing and seated. Or try one attached to a treadmill that allows you to slowly walk while you work.

In the car, park as far away as possible from the door so you’ll be able to walk more. Stand if you ride the bus or subway.

At home, get up regularly from your computer. Try standing and doing chores while watching TV.
Incorporating short bursts of standing and movement like this will keep you from becoming an “active couch potato,” someone who exercises and then remains largely sedentary the rest of the time. By thinking of fitness as something that entails what you do the entire day — not just the relatively few minutes spent sweating — you’ll be able to fully reap the rewards of your workouts.

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